abstract：:Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. We have identified, isolated and sequenced a new gene, augmenter of liver regeneration (ALR) t...

journal_title：International journal of experimental pathology

authors： Polimeno L,Pesetti B,Giorgio F,Moretti B,Resta L,Rossi R,Annoscia E,Patella V,Notarnicola A,Mallamaci R,Francavilla A

更新日期：2009-08-01 00:00:00

abstract：:Formation of the coronary arteries consists of a precisely orchestrated series of morphogenetic and molecular events which can be divided into three distinct processes: vasculogenesis, angiogenesis and arteriogenesis (Risau 1997; Carmeliet 2000). Even subtle perturbations in this process may lead to congenital coronar...

journal_title：International journal of experimental pathology

authors： Smart N,Dubé KN,Riley PR

更新日期：2009-06-01 00:00:00

abstract：:Plasmodium berghei ANKA (PbA) infection in susceptible inbred mouse strains is the most commonly used experimental model to study pathogenesis of cerebral malaria (CM). Indeed, many concepts on mechanisms related to this complication have arisen from works using this model. Although inbred strains present several adva...

journal_title：International journal of experimental pathology

authors： Martins YC,Smith MJ,Pelajo-Machado M,Werneck GL,Lenzi HL,Daniel-Ribeiro CT,Carvalho LJ

更新日期：2009-04-01 00:00:00

abstract：:The tumour microenvironment, which is largely composed of inflammatory cells, is a crucial participant in the neoplastic process through the promotion of cell proliferation, survival and migration. Neutrophil polymorphonuclear cells (PMNs) induce inflammatory reactions that can be either cytotoxic for tumour cells or ...

journal_title：International journal of experimental pathology

authors： Remedi MM,Donadio AC,Chiabrando GA

更新日期：2009-02-01 00:00:00

abstract：:The liver sinusoidal endothelial cell (LSEC) is damaged by many toxins, including oxidants and bacterial toxins. Any effect on LSECs of the Pseudomonas aeruginosa virulence factor, pyocyanin, may be relevant for systemic pseudomonal infections and liver transplantation. In this study, the effects of pyocyanin on in vi...

journal_title：International journal of experimental pathology

authors： Cheluvappa R,Cogger VC,Kwun SY,O'Reilly JN,Le Couteur DG,Hilmer SN

更新日期：2008-12-01 00:00:00

abstract：:It was previously shown that administration of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) aggravated murine viral myocarditis by increasing myocardial virus titres. Experimental autoimmune myocarditis in mice and rats mimics human fulminant myocarditis. The effects of L-arginine, a...

journal_title：International journal of experimental pathology

authors： Okabe TA,Hattori M,Yuan Z,Kishimoto C

更新日期：2008-10-01 00:00:00

abstract：:Reduced expression of endothelial nitric oxide synthase (eNOS) in chronic liver disease can reduce hepatic perfusion and accelerate fibrosis. The relationship between eNOS expression and liver fibrogenesis remains unclear. We investigated whether L-arginine attenuated chronic liver fibrosis through eNOS expression. Ch...

journal_title：International journal of experimental pathology

authors： Leung TM,Tipoe GL,Liong EC,Lau TY,Fung ML,Nanji AA

更新日期：2008-08-01 00:00:00

abstract：:(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH. In the present study, the activity of G6PD, ...

journal_title：International journal of experimental pathology

authors： Frederiks WM,Vizan P,Bosch KS,Vreeling-Sindelárová H,Boren J,Cascante M

更新日期：2008-08-01 00:00:00

abstract：:The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by pa...

journal_title：International journal of experimental pathology

authors： Geerts AM,Vanheule E,Praet M,Van Vlierberghe H,De Vos M,Colle I

更新日期：2008-08-01 00:00:00

abstract：:Skin window procedures in humans have shown rapid accumulation of neutrophils into the exuded fluids above abraded skin. The present study was undertaken to determine if similar epicutaneous neutrophil accumulation might explain the extreme resistance of HRS/J mice, both hairless (hr/hr) and haired (hr/+), to experime...

journal_title：International journal of experimental pathology

authors： Hahn BL,Bischof TS,Sohnle PG

更新日期：2008-06-01 00:00:00

abstract：:This study aimed to characterize matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in relation to changes in left ventricle (LV) geometry and function in a porcine model with streptozotocin (STZ)-induced diabetes. In 15 Chinese Guizhou minipigs with STZ-induced diabetes (diabetic group) and 15 age-m...

journal_title：International journal of experimental pathology

authors： Lu L,Zhang Q,Pu LJ,Peng WH,Yan XX,Wang LJ,Chen QJ,Zhu ZB,Michel JB,Shen WF

更新日期：2008-04-01 00:00:00

abstract：:The effect of oestradiol on the intact and castrated adult gerbil prostate was evaluated by focussing on stromal and epithelial disorders, and hormonal receptor immunoreactivity. The experimental animals were studied by histological, histochemical and immunohistochemical techniques, morphometric-stereological analysis...

journal_title：International journal of experimental pathology

authors： Scarano WR,de Sousa DE,Campos SG,Corradi LS,Vilamaior PS,Taboga SR

更新日期：2008-02-01 00:00:00

abstract：:The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia. Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the...

journal_title：International journal of experimental pathology

authors： Campos SG,Zanetoni C,Scarano WR,Vilamaior PS,Taboga SR

更新日期：2008-02-01 00:00:00

abstract：:Pulmonary granuloma formation and fibrosis were experimentally induced in Sprague-Dawley strain rats by Angiostrongylus cantonensis. Increased protein levels of matrix metalloproteinase (MMP)-2, -9, -13 and the imbalance between these enzymes and metalloproteinase inhibitors, tissue inhibitors of MMPs (TIMP-1 and -2),...

journal_title：International journal of experimental pathology

authors： Hsu CC,Lai SC

更新日期：2007-12-01 00:00:00

abstract：:The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...

journal_title：International journal of experimental pathology

authors： Grant ME

更新日期：2007-08-01 00:00:00

abstract：:Polymorphonuclear cells (PMN) are believed to be important effector cells responsible the myocardial damage seen following ischaemia. However, the exact kinetics of their migration remains controversial. Isolated PMN (10 x 10(6) cells) labelled with (51)Cr were injected into four groups of Lewis rats: 0 h (T0h; n = 13...

journal_title：International journal of experimental pathology

authors： Légaré JF,Oxner A,Heimrath O,Issekutz T

更新日期：2007-08-01 00:00:00

abstract：:Minaçu virus was isolated from Ochlerotatus scapularis (Diptera: Culicidae) in Minaçu, Goiás State, Brazil, in 1996. In attempting characterization of virus serological (hemagluttination inhibition, HI; indirect immunofluorescence assay, IFA), physicochemical [test for deoxycholate acid (DCA) sensitivity; polyacrylami...

journal_title：International journal of experimental pathology

authors： Martins LC,Diniz JA,Silva EV,Barros VL,Monteiro HA,Azevedo RS,Quaresma JA,Vasconcelos PF

更新日期：2007-02-01 00:00:00

abstract：:The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

journal_title：International journal of experimental pathology

authors： Prado CM,Rossi MA

更新日期：2006-12-01 00:00:00

abstract：:Heart failure (HF) is characterized by a skeletal muscle myopathy with increased expression of fast myosin heavy chains (MHCs). The skeletal muscle-specific molecular regulatory mechanisms controlling MHC expression during HF have not been described. Myogenic regulatory factors (MRFs), a family of transcriptional fact...

journal_title：International journal of experimental pathology

authors： Carvalho RF,Cicogna AC,Campos GE,Lopes Fda S,Sugizaki MM,Nogueira CR,Pai-Silva MD

更新日期：2006-06-01 00:00:00

abstract：:Conventional therapies for low back pain (LBP) are purely symptomatic and do not target the cause of LBP, which in approximately 40% of cases is caused by degeneration of the intervertebral disc (DIVD). Targeting therapies to inhibit the process of degeneration would be a potentially valuable treatment for LBP. There ...

journal_title：International journal of experimental pathology

authors： Le Maitre CL,Freemont AJ,Hoyland JA

更新日期：2006-02-01 00:00:00

abstract：:The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The high-affinity interleukin-2 receptor (haIL-2R) is expressed on activated, but not quiescent, T lymphocytes. This selective expression of haIL-2R provides the bas...

journal_title：International journal of experimental pathology

authors： Segel MJ,Aqeilan R,Zilka K,Lorberboum-Galski H,Wallach-Dayan SB,Conner MW,Christensen TG,Breuer R

更新日期：2005-10-01 00:00:00

abstract：:An important means of determining how amyloid-beta peptide (Abeta) affects cells is to identify specific macromolecular targets and assess how Abeta interaction with such targets impacts on cellular functions. On the one hand, cell surface receptors interacting with extracellular Abeta have been identified, and their ...

journal_title：International journal of experimental pathology

authors： Yan SD,Stern DM

更新日期：2005-06-01 00:00:00

abstract：:In chronic administration of sodium valproate to rats, significant disorders of structural integrity of the hippocampal gyrus and the neocortex of the temporal lobe, observed in the last two stages of the experiment (after 9 and 12 months), coexisted with increased number of microglial cells and, especially after 12 m...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2005-04-01 00:00:00

abstract：:In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

journal_title：International journal of experimental pathology

authors： Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

更新日期：2005-02-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...

journal_title：International journal of experimental pathology

authors： Yoshimatsu M,Terasaki Y,Sakashita N,Kiyota E,Sato H,van der Laan LJ,Takeya M

更新日期：2004-12-01 00:00:00

abstract：:An autoimmune kidney disease morphologically and functionally similar to Heymann nephritis (HN) was induced in mature male Sprague Dawley rats by repeated weekly IP injections of a chemically modified azo sonicated ultracentrifuged (u/c) rat kidney fraction 3 (rKF3) antigen in an aqueous medium. The experiment was ter...

journal_title：International journal of experimental pathology

authors： Barabas AZ,Cole CD,Barabas AD,Lafreniere R

更新日期：2004-10-01 00:00:00

abstract：:Administration of mercuric chloride (HgCl(2)) to Brown Norway rats causes Th2-dominated autoimmunity with raised immunoglobulin E concentrations and gut vasculitis, both of which are T-cell dependent, peak at 14 days after starting HgCl(2) and then spontaneously resolve. If animals are re-challenged with HgCl(2) 6 wee...

journal_title：International journal of experimental pathology

authors： Vinen CS,Turner DR,Oliveira DB

更新日期：2004-06-01 00:00:00

abstract：:C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...

journal_title：International journal of experimental pathology

authors： Pilling A,Jones S,Turton J

更新日期：2004-02-01 00:00:00

abstract：:The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...

journal_title：International journal of experimental pathology

authors： Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

更新日期：2003-10-01 00:00:00

abstract：:Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining muscle structure and function. Homologues of DMD have been identified in several animals including dogs, cats, mice, fish and invertebr...

journal_title：International journal of experimental pathology

authors： Collins CA,Morgan JE

更新日期：2003-08-01 00:00:00

abstract：:Small intestinal mucosal T cell activation results in villous atrophy and crypt hyperplasia. There is conflicting evidence as to whether a Th1 IFN-gamma response may be involved. Using a murine intestinal transplant model of T cell-mediated enteropathy we aimed to study the role of IFN-gamma on the development of vill...

journal_title：International journal of experimental pathology

authors： Veitch AM,Higgins LM,Bajaj-Elliot M,Farthing MJ,MacDonald TT

更新日期：2003-06-01 00:00:00

abstract：:Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

journal_title：International journal of experimental pathology

authors： Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

更新日期：2003-04-01 00:00:00

abstract：:Previously we have found deregulation of collagen metabolism in human pancreatitis and pancreatic cancer tissues. Insulin-like growth factor-I (IGF-I) is known to stimulate collagen biosynthesis through interaction with IGF-I receptor. IGF-I binding proteins (BPs) regulate the activity of IGF-I. We investigated whethe...

journal_title：International journal of experimental pathology

authors： Karna E,Surazynski A,Orłowski K,Łaszkiewicz J,Puchalski Z,Nawrat P,Pałka J

更新日期：2002-10-01 00:00:00

abstract：:The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is therefore an important component of the growth and function of these tissu...

journal_title：International journal of experimental pathology

authors： Reynolds LP,Grazul-Bilska AT,Redmer DA

更新日期：2002-08-01 00:00:00

abstract：:Intratracheal instillation (IT) of bleomycin is a widely used experimental model for lung fibrosis. In this study we describe the time-course of bleomycin-induced lung fibrosis in mice using computer-assisted morphometry. C57Bl/6J mice were treated with a single IT dose of bleomycin or control saline. Animals were kil...

journal_title：International journal of experimental pathology

authors： Izbicki G,Segel MJ,Christensen TG,Conner MW,Breuer R

更新日期：2002-06-01 00:00:00

abstract：:Long-term intragastric administration of the antiepileptic drug sodium valproate (Vuprol Polfa) to rats for 1, 3, 6, 9 and 12 months, once daily at the effective dose of 200 mg/kg body weight showed morphological evidence of encephalopathy, manifested by numerous nonspecific changes within Purkinje cell perikarya and ...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2001-12-01 00:00:00

abstract：:Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...

journal_title：International journal of experimental pathology

authors： Masuhara K,Nakata K,Yamasaki S,Miki H,Yoshikawa H

更新日期：2001-10-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) is a herpes virus which establishes a life-long persistent infection in over 90% of the human adult population world-wide. Based on its association with a variety of lymphoid and epithelial malignancies, EBV has been classified as a group 1 carcinogen by the International Agency for Resear...

journal_title：International journal of experimental pathology

authors： Niedobitek G,Meru N,Delecluse HJ

更新日期：2001-06-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of he...

journal_title：International journal of experimental pathology

authors： Arbuthnot P,Kew M

更新日期：2001-04-01 00:00:00

abstract：:The aim of the present study was to clarify the therapeutic effects of 1alpha, 25[OH]2 vitamin D3 (calcitriol) pulse injection on bone lesions induced in a rat model of chronic cadmium toxicosis. Ovariectomized (OVX) and control-operated (sham-OVX) rats were given repeated intravenous injections of 0.5 mg/kg/day CdCl2...

journal_title：International journal of experimental pathology

authors： Kurata Y,Katsuta O,Hiratsuka H,Tsuchitani M,Umemura T

更新日期：2001-02-01 00:00:00